Figure 9.

Inhibiting VEGF-R2 signaling improves functional recovery in diabetic mice. A, Sample image frames showing trial initiation and removal of adhesive tape from the forepaws (black arrow). B, Plots showing the change in time (Δ Latency) it took mice to remove adhesive tape from the left (impaired) and right (unimpaired) forepaw (n = 7–12 mice per group). BL, Baseline or prestroke tape removal latencies. C, Sample frames showing a correct and partial (incorrect) forepaw placement on the horizontal ladder. D, Histograms showing the percentage of correct or partial forepaw placements as a function of total steps taken. *p < 0.05, diabetic vehicle versus diabetic SU5416. †p < 0.05, diabetic vehicle versus nondiabetic vehicle. †† p < 0.01, diabetic vehicle versus nondiabetic vehicle.