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. 2015 Aug 26;35(34):12063–12079. doi: 10.1523/JNEUROSCI.0608-15.2015

Figure 8.

Figure 8.

The modulation of IGF-1R expression levels is sufficient to restore the AKT/CREB and ERK/Elk-1 intracellular signaling pathway activation profile, resulting in SMN expression increase in SMA mice. A–C, Proposed mechanisms involved in the increase of SMN expression induced by the genetic reduction of IGF-1R expression in severe SMA-like mice. Modulation of the activation profile of ERK/Elk-1 and AKT/CREB signaling pathways in control (A) compared with Igf-1r+/+ (B) and Igf-1r+/− SMA (C) mice at 12 d of age. Large characters indicate activated molecules.