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. 2015 Nov 25;35(47):15716–15730. doi: 10.1523/JNEUROSCI.0996-15.2015

Figure 4.

Figure 4.

18F-GE180 PET and AR signal were correlated with TSPO IR in hippocampus in 4- and 26-month-old WT and APP/PS1dE9 Tg mice. Hippocampal TSPO IR (% ROI; black bars) in 4- and 26-month-old WT and APP/PS1dE9 Tg mice was quantified by BioQuant software using % ROI (2 planes per mouse, n = 4–6 mice per group). The hippocampal in vivo PET signal during the 60–90 min period of dynamic acquisition (retention, A), ex vivo PET (B), or ex vivo AR (C) was also calculated, respectively, for each group (n = 6) and correlated with TSPO IR. ***p < 0.001, one-way ANOVA with post hoc Bonferroni's test.