Figure 7.

In the lateral line, RA pathway is already induced at 1.5 hpt. Expression pattern of components of the RA pathway detected by in situ hybridization in resting state and at various time points during regeneration. In regenerating neuromasts, expression of aldh1a3, rarab, rarga, and cyp26a1 was upregulated at 1.5 hpt, whereas cyp26c1 was upregulated at 3 hpt. sox2 and atoh1a were downregulated and upregulated at 1.5 hpt, respectively. After transient downregulation of sox2 at 1.5 hpt, expression is rapidly recovered by 3 hpt. Scale bar, 10 μm.