Figure 8.

RAR represses p27^kip and sox2 during hair cell regeneration but has no effect on fgf3. A–C, p27^kip is expressed in the supporting cells of neuromasts under wild-type conditions (A), but it is strongly downregulated 1.5 h after hair cell damage (B), allowing supporting cells to reenter the cell cycle. C, Two representative neuromasts showing that the dnRAR-expressing cells are unable to downregulate p27^kip transcription. D–F, sox2 is expressed in the supporting cells of a neuromast in a 4.5 dpf larva under resting conditions (D) but downregulated 1.5 h after neomycin treatment (E). F, Two representative examples of neuromasts overexpressing dnRAR show inhibition of sox2 downregulation. G–I, fgf3 is normally expressed in resting conditions (G), and it is repressed 1.5 h after neomycin (H). I, Overexpression of dnRAR does not alter the fgf3 downregulation after cell damage. J–L, Similarly, overexpression of FGF3 does not affect aldh1a3 expression in regenerating neuromasts 3 hpt.