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. 2016 Apr 6;36(14):3890–3902. doi: 10.1523/JNEUROSCI.4486-15.2016

Figure 6.

Figure 6.

Parthenolide treatment accelerates functional recovery after sciatic nerve injury. A, Representative pictures of right hindpaws of wt mice intraneurally injected with either vehicle (veh) or 6.25 pg parthenolide (par) and tested before (con) and 1, 4, 9, 14, and 21 d after SNC (dpc). B, Quantification of motor function recovery in adult mice treated as depicted in A using the SSI. Eleven animals were analyzed per experimental group. Treatment effects: ***p ≤ 0.001. C, Extensor hallucis longus muscle whole mounts from veh- or par-treated mice stained with α-BTX (red) and 200 kDa neurofilament antibody (NF, green) 4 d after SNC. White arrows indicate reestablished synapses in par-treated mice. Scale bar, 50 μm. D, Quantification of sensory function recovery of adult wt mice intraneurally injected with either veh or par and tested at 1, 4, 7, 9, 12, 14, and 21 d after SNC using the von Frey test. Eleven animals were analyzed per experimental group. Treatment effects: ***p ≤ 0.001.