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. 2016 Jul 13;36(28):7511–7522. doi: 10.1523/JNEUROSCI.0462-16.2016

Figure 4.

Figure 4.

The Ala1632Gly mutation increases evoked firing frequency in small DRG neurons. Responses of a small DRG neuron expressing WT (A–C) or Ala1632Gly (D–F) hNav1.7 channels to 500 ms depolarizing current steps that are onefold (A, D), twofold (B, E), and threefold (C, F) of its threshold, respectively. G, Summary of firing frequency in response to graded inputs. Error bars indicate SEM. *p < 0.05. H, Resting membrane potential of neurons expressing Ala1632Gly displays a mild depolarization of 1.8 mV compared with neurons expressing WT, but this depolarization does not reach statistical significance (p = 0.189).