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. 2016 Jul 13;36(28):7392–7406. doi: 10.1523/JNEUROSCI.4061-15.2016

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Copyright © 2016 the authors 0270-6474/16/367392-15$15.00/0

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Figure 1. — Serotonin inhibits TIDA neurons. A, Current-clamp, oscillating rat TIDA neuron. 5-HT (10 μm) application results in hyperpolarization and abolishment of phasic discharge. Calibration: 20 mV, 30 s. Bottom, Expanded sections highlighted in A with the color-coordinated 1 Hz filter superimposed and the corresponding spectral analysis opposite. Calibration: 20 mV, 2 s. B, Frequency spectrogram of the entire trace depicted in A. There is reversible abolishment of TIDA oscillation power by 5-HT. C, Confocal micrographs from rat hypothalamus stained by immunofluorescence for TH (red) and 5-HT (green). Boxed area enlarged in Inset. 5-HT-immunoreactive terminals form close appositions on somata (filled arrows) and dendrites (open arrows) of TH-expressing TIDA neurons. Scale bars: 100 μm; Inset, 10 μm. 3V, Third ventricle; ARC, arcuate nucleus.