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. 2016 Jul 13;36(28):7392–7406. doi: 10.1523/JNEUROSCI.4061-15.2016

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Copyright © 2016 the authors 0270-6474/16/367392-15$15.00/0

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Figure 8. — Supraclinical concentrations of fluoxetine abolish the TIDA oscillation. A, Voltage-clamp trace of an oscillating TIDA neuron. Application of 100 μm fluoxetine gradually abolishes TIDA oscillation. Calibration: 20 pA, 2 min. B, Enlarged color-coded 100 s boxed sections in D filtered at 1 Hz. There is gradual reduction in oscillation amplitude and frequency. Calibration: 10 pA, 5 s. C, Average oscillation cycle amplitude and duration from the color-coded data depicted in B. D, Spectral density plots of the color-coded data depicted in B. There is successively reduced oscillation strength and peak frequency.