Table 2.
Changes in VACHT immunoreactivity in male APOE3 and APOE4 mice
| 30 dpl |
70 dpl |
170 dpl |
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sh.e3 | Les.e3 | p | Sh.e4 | Les.e4 | p | Sh.e3 | Les.e3 | p | Sh.e4 | Les.e4 | p | Sh.e3 | Les.e3 | p | Sh.e4 | Les.e4 | p | |
| DG oML | 1 ± 0.04 | 0.93 ± 0.10 | 0.73 | 1 ± 0.09 | 0.85 ± 0.07 | 0.59 | 1 ± 0.05 | 1.16 ± 0.09 | 0.32 | 1 ± 0.09 | 0.88 ± 0.06 | 0.35 | 1 ± 0.11 | 1.23 ± 0.09 | 0.15 | 1 ± 0.18 | 0.84 ± 0.11 | 0.31 |
| DG mML | 1 ± 0.08 | 1.39 ± 0.13 | 0.03 | 1 ± 0.06 | 0.90 ± 0.07 | 0.65 | 1 ± 0.06 | 1.43 ± 0.04 | 0.01 | 1 ± 0.11 | 1.01 ± 0.11 | 0.97 | 1 ± 0.14 | 1.03 ± 0.10 | 0.81 | 1 ± 0.16 | 0.81 ± 0.11 | 0.24 |
| DG iML | 1 ± 0.11 | 0.92 ± 0.12 | 0.67 | 1 ± 0.07 | 0.78 ± 0.07 | 0.17 | 1 ± 0.08 | 1.12 ± 0.05 | 0.46 | 1 ± 0.09 | 0.88 ± 0.07 | 0.46 | 1 ± 0.12 | 0.88 ± 0.08 | 0.48 | 1 ± 0.15 | 0.70 ± 0.09 | 0.06 |
| DG HIL | 1 ± 0.13 | 1.04 ± 0.12 | 0.80 | 1 ± 0.10 | 0.92 ± 0.07 | 0.67 | 1 ± 0.18 | 1.55 ± 0.17 | 0.01 | 1 ± 0.07 | 0.84 ± 0.06 | 0.27 | 1 ± 0.15 | 0.93 ± 0.14 | 0.70 | 1 ± 0.27 | 0.89 ± 0.13 | 0.49 |
| CA3 oLM | 1 ± 0.17 | 1.14 ± 0.14 | 0.49 | 1 ± 0.11 | 0.86 ± 0.08 | 0.34 | 1 ± 0.09 | 1.13 ± 0.13 | 0.51 | 1 ± 0.14 | 0.86 ± 0.10 | 0.60 | 1 ± 0.15 | 1.14 ± 0.15 | 0.467 | 1 ± 0.20 | 0.81 ± 0.12 | 0.31 |
| CA3 iLM | 1 ± 0.18 | 1.13 ± 0.10 | 0.51 | 1 ± 0.13 | 0.90 ± 0.07 | 0.43 | 1 ± 0.09 | 1.18 ± 0.10 | 0.36 | 1 ± 0.10 | 0.87 ± 0.10 | 0.53 | 1 ± 0.13 | 1.17 ± 0.12 | 0.36 | 1 ± 0.19 | 0.86 ± 0.13 | 0.45 |
| CA3 RAD | 1 ± 0.11 | 1.24 ± 0.13 | 0.25 | 1 ± 0.08 | 0.94 ± 0.06 | 0.61 | 1 ± 0.10 | 1.33 ± 0.11 | 0.09 | 1 ± 0.16 | 0.90 ± 0.06 | 0.56 | 1 ± 0.18 | 1.11 ± 0.12 | 0.58 | 1 ± 0.18 | 0.86 ± 0.10 | 0.46 |
| CA3 LUC | 1 ± 0.24 | 1.37 ± 0.29 | 0.07 | 1 ± 0.12 | 0.93 ± 0.09 | 0.40 | 1 ± 0.16 | 1.39 ± 0.21 | 0.06 | 1 ± 0.09 | 0.77 ± 0.07 | 0.16 | 1 ± 0.15 | 0.76 ± 0.14 | 0.22 | 1 ± 0.23 | 0.90 ± 0.14 | 0.59 |
| CA3 OR | 1 ± 0.06 | 1.19 ± 0.12 | 0.35 | 1 ± 0.03 | 0.91 ± 0.04 | 0.51 | 1 ± 0.08 | 1.38 ± 0.07 | 0.04 | 1 ± 0.08 | 0.86 ± 0.09 | 0.46 | 1 ± 0.09 | 1.14 ± 0.12 | 0.46 | 1 ± 0.15 | 0.74 ± 0.07 | 0.16 |
| CA2 oLM | 1 ± 0.16 | 1.18 ± 0.18 | 0.42 | 1 ± 0.15 | 0.90 ± 0.09 | 0.64 | 1 ± 0.12 | 1.12 ± 0.13 | 0.58 | 1 ± 0.09 | 0.92 ± 0.11 | 0.85 | 1 ± 0.15 | 1.02 ± 0.14 | 0.90 | 1 ± 0.24 | 0.98 ± 0.15 | 0.93 |
| CA2 iLM | 1 ± 0.12 | 1.31 ± 0.19 | 0.18 | 1 ± 0.11 | 1.10 ± 0.10 | 0.69 | 1 ± 0.10 | 1.23 ± 0.12 | 0.33 | 1 ± 0.17 | 0.93 ± 0.08 | 0.85 | 1 ± 0.12 | 1.02 ± 0.14 | 0.92 | 1 ± 0.25 | 0.91 ± 0.14 | 0.67 |
| CA2 RAD | 1 ± 0.09 | 1.07 ± 0.13 | 0.73 | 1 ± 0.10 | 1.02 ± 0.08 | 0.87 | 1 ± 0.12 | 1.11 ± 0.16 | 0.60 | 1 ± 0.10 | 0.83 ± 0.07 | 0.49 | 1 ± 0.22 | 1.12 ± 0.19 | 0.55 | 1 ± 0.20 | 0.78 ± 0.11 | 0.29 |
| CA2 OR | 1 ± 0.14 | 1.07 ± 0.20 | 0.75 | 1 ± 0.11 | 0.99 ± 0.05 | 0.85 | 1 ± 0.04 | 1.61 ± 0.23 | 0.01 | 1 ± 0.17 | 0.87 ± 0.08 | 0.52 | 1 ± 0.16 | 1.11 ± 0.17 | 0.61 | 1 ± 0.22 | 0.82 ± 0.09 | 0.40 |
| CA1 LM | 1 ± 0.01 | 1.16 ± 0.14 | 0.50 | 1 ± 0.06 | 0.97 ± 0.04 | 0.99 | 1 ± 0.09 | 1.37 ± 0.12 | 0.10 | 1 ± 0.07 | 0.91 ± 0.06 | 0.57 | 1 ± 0.11 | 1.06 ± 0.12 | 0.77 | 1 ± 0.16 | 0.80 ± 0.10 | 0.36 |
| CA1 RAD | 1 ± 0.11 | 1.00 ± 0.18 | 0.99 | 1 ± 0.15 | 0.82 ± 0.10 | 0.37 | 1 ± 0.19 | 1.36 ± 0.19 | 0.11 | 1 ± 0.10 | 0.91 ± 0.10 | 0.51 | 1 ± 0.12 | 0.97 ± 0.16 | 0.91 | 1 ± 0.22 | 0.75 ± 0.10 | 0.24 |
| CA1 OR | 1 ± 0.08 | 1.28 ± 0.29 | 0.24 | 1 ± 0.14 | 0.70 ± 0.10 | 0.29 | 1 ± 0.16 | 1.80 ± 0.26 | 0.01 | 1 ± 0.26 | 0.76 ± 0.11 | 0.18 | 1 ± 0.18 | 0.79 ± 0.10 | 0.36 | 1 ± 0.33 | 0.65 ± 0.09 | 0.11 |
VACHT immunoreactivity levels are provided for all male groups (expressed as a ratio of respective sham group). Significant differences (p < 0.05, Fisher's LSD) are highlighted in red. Data are presented as mean ± SEM.