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. Author manuscript; available in PMC: 2020 Aug 19.
Published in final edited form as: ACS Appl Bio Mater. 2019 Jul 4;2(8):3540–3550. doi: 10.1021/acsabm.9b00419

Figure 10.

Figure 10.

Histology of pancreas and testis tissues derived from rats treated with 10 doses of PLGA or PLGA–GA nanosystems. No major histological abnormalities were seen in both the tissues. In the pancreas, yellow arrows show intact pancreatic “islets”, and the number of islets is insignificant between both the treatment groups suggesting PLGA–GA is safe. In testis, the absence of obvious changes such as cytoplasmic vacuolation, necrosis, apoptosis, and atrophy indicates PLGA–GA particles are safe.