Table 2.
Genotype | Age (mo) | Major affected brain regions |
Fear conditioning |
Open-field |
Rotarod | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
CB | RSG | Cg | Hippocampus | Acquisition | Context | Cued | Activity | Center | |||
Cbln1-null | 1 | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | → | ↓ |
3–5 | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ↑ | ↓ | |
FB-Cbln1-null | 1 | → | → | → | ↓ | → | ↓ | ↓ | → | → | → |
3–5 | → | ↓ | → | ↓ | → | ↓ | ↓ | → | → | → | |
CB-Cbln1-null | 1 | ↓ | ↓ | → | → | ↓ | ↓* | ↓ | → | → | ↓ |
3–5 | ↓ | ↓ | ↓ | → | ↓ | ↓ | ↓ | →↓ | ↑ | ↓ |
↓, reduced; →, no change; →↓, tendency to reduce.
*Reduced at 10 min but not at 24 h after conditioning.