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. 2017 Jan 4;37(1):47–57. doi: 10.1523/JNEUROSCI.1079-16.2016

Figure 1.

Figure 1.

α-Synuclein overexpression in cholinergic neurons of the DMV in A53T-SNCA mice. A, Human α-synuclein immunohistochemistry in coronal slices of the caudal brainstem in wild-typeNbm (left) and A53T-SNCANbm (right) mice. Nbm subscript denotes the modified Nussbaum model (Gispert et al., 2003; Subramaniam et al., 2014). XII n., Hypoglossal nucleus B. Human α-synuclein (green) and ChAT (red) immunohistochemistry in DMV in wild-typeVle (left) and A53T-SNCAVle (right) mice. Vle subscript denotes the Lee model (Giasson et al., 2002). C, Optical density measurements of the immunointensity of α-synuclein (green) expression within regions of interest determined from the ChAT (red) expression (dotted region is for illustration) reveals a rightward shift in the distribution of immunointensity values from A53T-SNCA relative to wild-type DMV neurons.