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The behavior of wild-type CREB compared with two mutant CREBs. A, B, Distribution histograms show the short (≤1 s; A) and long (>1 s; B) residence times of TMR-CREB, TMR-mutant CREB (R301L), and TMR-mutant CREB (L318/325V) in living neurons. The number of spots analyzed in living cells is presented in parentheses.
