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. 2017 Feb 8;37(6):1413–1427. doi: 10.1523/JNEUROSCI.2462-16.2016

Figure 5.

Figure 5.

MM218 rescues motor neurons in SOD1G93A astrocyte–spinal neuron cocultures through inhibition of EMMPRIN activation. A, Nontransgenic astrocyte–spinal neuron cocultures treated for 6 d with 5 nm MM218 or CsA or ethanol (Vehicle). CsA, but not MM218, was toxic to motor neurons (MNs). Data (mean ± SEM, 6–8 wells per condition) are percentages of untreated (Unt). *p < 0.05 versus Unt by one-way ANOVA, Bonferroni's multiple-comparisons test. B, SOD1G93A astrocyte–spinal neuron cocultures treated for 6 d with increased concentrations of MM218. Data (mean ± SEM, n = 6–8 wells per condition) are percentages of nontransgenic untreated cocultures (Ntg Unt). *p < 0.05 by one-way ANOVA, Bonferroni's multiple-comparisons test. C, Levels of MMP-9 were measured by AlphaLISA in the medium of SOD1G93A astrocyte–spinal neuron cocultures treated for 6 d with increasing concentrations of MM218. Data (mean ± SEM, 6–8 wells per condition) are in picograms per milliliter. *p < 0.05 by one-way ANOVA, Fisher's least significant difference test. Experiments in A–C were repeated several times, with consistent results.