Figure 5.
Alpha2b-adrenoceptor gene (ADRA2B) effects on brain connectivity. A, Regardless of stress, carriers of the ADRA2B deletion variant showed stronger functional connectivity between the left amygdala and the right entorhinal cortex (pFWE < 0.05). B, ADRA2B genotype additionally modulates stress-induced changes in amygdala-putamen connectivity. Under stress, noncarriers of the deletion variant showed significantly increased amygdala-putamen connectivity than carriers of the ADRA2B deletion variant (pFWE = 0.006), whereas genotype groups did not differ under control conditions (pFWE = 0.352). Activations are superimposed on coronal axial sections of a T1-weighted template image (red). Blue represents anatomical masks. L, Left side of the brain; R, right side of the brain. Error bars indicate SEM.