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. 2017 Jun 28;37(26):6253–6267. doi: 10.1523/JNEUROSCI.1529-16.2017

Figure 7.

Figure 7.

Microinjections of oxotremorine into the striatum and cerebellum induce abnormal movements. A, Nissl staining showing the bilateral cannula placement in the striatum. White arrows indicate the tip of cannulas. B, Abnormal motor scores (mean 10 min scores) 30–60 min after microinjection of vehicle or oxotremorine (0.1 μg) into the striatum in Gnal+/+ and Gnal+/− mice. Two-way ANOVA: treatment, F(1,13) = 11.9, p < 0.01; genotype, F(1,13) = 6.7, p < 0.05; interaction, F(1,13) = 0.8, p = 0.4. C, Nissl staining showing the bilateral cannula placement into the cerebellum. D, Abnormal motor scores (mean 10 min scores) 20–60 min after microinjection of vehicle or oxotremorine (0.1 μg) into the cerebellum in Gnal+/+ and Gnal+/− mice. Two-way ANOVA: treatment, F(1,26) = 17.0, p < 0.001; genotype, F(1,26) = 0.62, p = 0.4; interaction, F(1,26) = 0.82, p = 0.4. Data are shown as means ± SEM. *p < 0.05; **p < 0.01, ns not significant, Sidak's multiple-comparisons test after two-way ANOVA.