Table 1.
Prefrontal cortex fatty acid composition in adult C57Bl6/J mice fed n-3-balanced (n-3) or deficient (n-3-deficient) diet expressed as % of total fatty acid (n = 4 per group)
| Diet fatty acids | n-3 | n-3-deficient | Statistical effect |
|---|---|---|---|
| 14:0 | 0.2 ± 0.01 | 0.2 ± 0.01 | NS |
| 15:0 | 0.05 ± 0.002 | 0.06 ± 0.005 | NS |
| 16:0 | 22.5 ± 0.37 | 22.6 ± 0.61 | NS |
| 17:0 | 0.1 ± 0.01 | 0.1 ± 0.01 | NS |
| 18:0 | 22.1 ± 0.33 | 22.1 ± 0.42 | NS |
| 20:0 | 0.2 ± 0.01 | 0.2 ± 0.02 | NS |
| 22:0 | 0.2 ± 0.02 | 0.2 ± 0.04 | NS |
| 24:0 | 0.2 ± 0.03 | 0.3 ± 0.06 | NS |
| Saturated | 45.6 ± 0.10 | 45.7 ± 0.49 | NS |
| 16:1n-9 | 0.2 ± 0.01 | 0.2 ± 0.01 | NS |
| 16:1n-7 | 0.6 ± 0.02 | 0.6 ± 0.03 | NS |
| 17:1n-9 | 0.04 ± 0.016 | 0.03 ± 0.005 | NS |
| 18:1trans | 0.06 ± 0.009 | 0.06 ± 0.006 | NS |
| 18:1n-9 | 11.9 ± 0.20 | 11.8 ± 0.33 | NS |
| 18:1n-7 | 3.1 ± 0.04 | 3.2 ± 0.02 | NS |
| 20:1n-9 | 0.6 ± 0.03 | 0.6 ± 0.09 | NS |
| 20:1n-7 | 0.14 ± 0.009 | 0.18 ± 0.019 | NS |
| 22:1n-9 | 0.06 ± 0.005 | 0.06 ± 0.012 | NS |
| 24:1n-9 | 0.4 ± 0.07 | 0.6 ± 0.01 | NS |
| Monounsaturated | 17.1 ± 0.28 | 17.4 ± 0.57 | NS |
| 18:2n-6 | 0.3 ± 0.01 | 0.5 ± 0.02 | <0.0001 |
| 20:2n-6 | 0.1 ± 0.01 | 0.1 ± 0.01 | NS |
| 20:3n-6 | 0.3 ± 0.01 | 0.3 ± 0.01 | <0.0001 |
| 20:4n-6 | 9.8 ± 0.15 | 10.1 ± 0.19 | NS |
| 22:4n-6 | 2.1 ± 0.08 | 2.4 ± 0.05 | <0.01 |
| 22:5n-6 | 0.6 ± 0.02 | 2.6 ± 0.21 | <0.0001 |
| n-6 | 13.2 ± 0.17 | 16.0 ± 0.29 | <0.0001 |
| 22:5n-3 | 0.2 ± 0.01 | 0.1 ± 0.01 | <0.01 |
| 22:6n-3 | 17.4 ± 0.09 | 14.0 ± 0.42 | <0.0001 |
| n-3 | 17.6 ± 0.09 | 14.1 ± 0.42 | <0.0001 |
| 20:3n-9 | 0.1 ± 0.00 | 0.1 ± 0.01 | <0.001 |
| Polyunsaturated | 30.9 ± 0.21 | 30.2 ± 0.60 | NS |
| DMA16:0 | 1.7 ± 0.05 | 1.7 ± 0.10 | NS |
| DMA18:0 | 3.3 ± 0.01 | 3.2 ± 0.08 | NS |
| DMA18:1n-9 | 0.7 ± 0.03 | 0.8 ± 0.10 | NS |
| DMA18:1n-7 | 0.7 ± 0.03 | 0.9 ± 0.10 | NS |
| DMA | 6.4 ± 0.07 | 6.6 ± 0.36 | NS |
| n-6/n-3 | 0.7 ± 0.01 | 1.1 ± 0.03 | <0.0001 |
| AA/DHA | 0.6 ± 0.01 | 0.7 ± 0.01 | <0.0001 |
| u.i. | 174.8 ± 0.77 | 167.7 ± 2.71 | <0.05 |
DMA, Dimethylacetal; AA, arachidonic acid, 20:4 n-6; DHA, docosahexaenoic acid, 22:6; SFAs, saturated fatty acids; MUFAs, monounsaturated fatty acids; LA, linoleic acid, 18:2 n-6; n-6 DPA, docosapentaenoic acid, 22:5 n-6; n-3 DPA, docosapentaenoic acid, 22:5 n-3. Adolescence to adulthood n-3 deprivation modifies mPFC fatty acid composition. Fatty acid composition in mice fed with n-3-balanced or n-3-deficient diet from PND 28 to PND 90. Results are expressed as percentage of total fatty acids (n = 4).