Table 2.
Nucleus accumbens fatty acid composition in adult C57Bl6/J mice fed n-3-balanced or n-3-deficient diet expressed as percentage of total fatty acid (n = 4 per group)
| Diet fatty acids | n-3 | n-3-deficient | Statistical effect |
|---|---|---|---|
| 14:0 | 0.2 ± 0.02 | 0.2 ± 0.02 | NS |
| 15:0 | 0.03 ± 0.012 | 0.06 ± 0.07 | NS |
| 16:0 | 19.2 ± 0.61 | 21.0 ± 0.79 | NS |
| 17:0 | 0.12 ± 0.005 | 0.13 ± 0.000 | NS |
| 18:0 | 23.1 ± 0.55 | 22.2 ± 0.39 | NS |
| 20:0 | 0.3 ± 0.03 | 0.3 ± 0.01 | NS |
| 22:0 | 0.3 ± 0.04 | 0.3 ± 0.02 | NS |
| 24:0 | 0.6 ± 0.13 | 0.3 ± 0.02 | NS |
| Saturated | 43.8 ± 0.44 | 44.5 ± 0.44 | NS |
| 16:1n-9 | 0.15 ± 0.002 | 0.15 ± 0.005 | NS |
| 16:1n-7 | 0.6 ± 0.03 | 0.6 ± 0.01 | NS |
| 17:1n-9 | 0.11 ± 0.008 | 0.07 ± 0.026 | NS |
| 18:1trans | 0.09 ± 0.013 | 0.07 ± 0.007 | NS |
| 18:1n-9 | 13.2 ± 0.03 | 13.1 ± 0.10 | NS |
| 18:1n-7 | 3.3 ± 0.04 | 3.4 ± 0.03 | 0.05 |
| 20:1n-9 | 1.1 ± 0.06 | 1.0 ± 0.07 | NS |
| 20:1n-7 | 0.2 ± 0.018 | 0.2 ± 0.010 | NS |
| 22:1n-9 | 0.18 ± 0.048 | 0.09 ± 0.012 | NS |
| 24:1n-9 | 1.0 ± 0.11 | 0.8 ± 0.05 | NS |
| Monounsaturated | 20.0 ± 0.18 | 19.5 ± 0.23 | NS |
| 18:2n-6 | 0.3 ± 0.02 | 0.5 ± 0.02 | <0.01 |
| 20:2n-6 | 0.13 ± 0.023 | 0.14 ± 0.018 | NS |
| 20:3n-6 | 0.4 ± 0.03 | 0.3 ± 0.01 | <0.05 |
| 20:4n-6 | 10.4 ± 0.17 | 10.6 ± 0.23 | NS |
| 22:4n-6 | 2.7 ± 0.06 | 2.7 ± 0.04 | NS |
| 22:5n-6 | 0.5 ± 0.09 | 1.8 ± 0.05 | <0.0001 |
| n-6 | 14.4 ± 0.23 | 16.0 ± 0.30 | <0.01 |
| 22:5n-3 | 0.4 ± 0.06 | 0.1 ± 0.04 | <0.05 |
| 22:6n-3 | 14.3 ± 0.31 | 12.1 ± 0.22 | <0.01 |
| n-3 | 14.7 ± 0.32 | 12.2 ± 0.19 | <0.001 |
| 20:3n-9 | 0.16 ± 0.032 | 0.07 ± 0.015 | <0.05 |
| Polyunsaturated | 29.2 ± 1.15 | 28.3 ± 0.45 | NS |
| DMA16:0 | 1.9 ± 0.22 | 2.3 ± 0.17 | NS |
| DMA18:0 | 3.3 ± 0.11 | 3.4 ± 0.06 | NS |
| DMA18:1n-9 | 0.8 ± 0.05 | 0.9 ± 0.03 | NS |
| DMA18:1n-7 | 1.0 ± 0.06 | 1.1 ± 0.03 | NS |
| DMA | 7.0 ± 0.41 | 7.7 ± 0.23 | NS |
| n-6/n-3 | 1.0 ± 0.01 | 1.3 ± 0.02 | <0.0001 |
| AA/DHA | 0.72 ± 0.01 | 0.88 ± 0.01 | <0.0001 |
| u.i. | 174.8 ± 0.77 | 167.7 ± 2.71 | <0.05 |
DMA, Dimethylacetal; AA, arachidonic acid, 20:4 n-6; DHA, docosahexaenoic acid, 22:6; SFAs, saturated fatty acids; MUFAs, monounsaturated fatty acids; LA, linoleic acid, 18:2 n-6; n-6 DPA, docosapentaenoic acid, 22:5 n-6; n-3 DPA, docosapentaenoic acid, 22:5 n-3. Adolescence to adulthood n-3 deprivation modifies mPFC fatty acid composition. Fatty acid composition in mice fed with n-3-balanced or n-3-deficient diet from PND 28 to PND 90. Results are expressed as percentage of total fatty acids (n = 4).