Table 4. Estimates of distributions of immune cells, fused cells and fusion susceptibility by immune cell phenotype in ZM247Fv2-infected peripheral blood cells.
| Immune cell phenotype | Immune cellsa Median #c (Mean %) |
Fused cellsb Median #c (Mean %) |
Fusion susceptibilitya Mean % |
|---|---|---|---|
| Total | 524,000 (100%) | 5,771 (100%) | 1.28% |
| Monocytes | 27,441 (5.5%) | 724 (12.2%) | 0.16% |
| LIN- | 30,813 (7.0%) | 517 (8.2%) | 0.10% |
| CD14- CD3- DR+ LIN-CD303- | 29,986 (6.8%) | 322 (5.7%) | 0.074% |
| Myeloid DCs: CD141- CD1c+ | 252 (0.056%) | 6 (0.11%) | 0.001% |
| Myeloid DCs: CD141+ CD1c- | 101 (0.021%) | 4 (0.086%) | 0.001% |
| Myeloid DCs: CD141+ CD1c+ | 1,043 (0.22%) | 51 (1.02%) | 0.013% |
| Other antigen-presenting cells: CD141-CD1c- | 28,380 (6.5%) | 257 (4.8%) | 0.063% |
| Plasmacytoid DCs | 894 (0.2%) | 142 (2.3%) | 0.030% |
| CD4- T-cells | 149,300 (29.0%) | 28 (0.58%) | 0.007% |
| CD4+ T-cells | 196,756 (39.3%) | 4,212 (76.3%) | 0.98% |
| CD4+ T-cells (RO- 69-) | 115,909 (24.6%) | 308 (8.4%) | 0.11% |
| CD4+ T-cells (RO- 69+) | 135 (0.030%) | 12 (0.21%) | 0.003% |
| CD4+ T-cells (RO+ 69-) | 71,936 (14.8%) | 3,887 (66.5%) | 0.87% |
| CD4+ T-cells (RO+ 69+) | 109 (0.022%) | 9 (0.15%) | 0.002% |
| Other cell types | 57,370 (10.0%) | 45 (1.28%) | 0.033% |
a Denominator is the total number of immune cells.
b Denominator is the total number of fused cells.
c Counts (#) are medians across 53 participants. For medians, sum of components can differ from total.
Percents (%) are means estimated from generalized linear models (binomial distribution with logit link).