Table 1. Patients characteristics (n = 30) and distribution according to either low or high hypoxia-inducible factor 1 alpha (HIF-1α) expression.
| Variable | HIF-1α low | HIF-1α high | p |
|---|---|---|---|
| Age * | 67 [49–86] | 57 [47–72] | 0.206 |
| BMI * | 26 [17–34] | 27 [24–40] | 0.188 |
| CA 12–5 * | 369 [16–1673] | 483 [69–952] | 0.957 |
| Disease variable | n (%) | n (%) | |
| Grade | 0.892 | ||
| 1 | 1 (3.3) | 0 (0.0) | |
| 2 | 8 (26.7) | 2 (6.7) | |
| 3 | 16 (53.3) | 3 (10.0) | |
| FIGO stage | 0.900 | ||
| 1 | 4 (13.3) | 1 (3.3) | |
| 2 | 2 (6.7) | 0 (0.0) | |
| 3 | 11 (36.7) | 2 (6.7) | |
| 4 | 8 (26.7) | 2 (6.7) | |
| Histology | 0.952 | ||
| High grade serous | 17 (56.7) | 3 (10.0) | |
| Endometrioid | 4 (13.3) | 1 (3.3) | |
| Mucinous | 0 (0.0) | 0 (0) | |
| Clear cell | 1 (3.3) | 0 (0) | |
| Other histology | 3 (10.0) | 1 (3.3) | |
| Ascites | 0.968 | ||
| No | 5 (16.7) | 1 (3.3) | |
| Yes | 20 (66.7) | 4 (13.3) | |
| Residual tumor at primary surgery | 0.348 | ||
| No | 14 (46.7) | 1 (3.3) | |
| </ = 1cm | 9 (30.0) | 3 (10.0) | |
| >1cm | 2 (6.7) | 1 (3.3) | |
| Tumor recurrence | 0.692 | ||
| No | 10 (40.0) | 1 (4.0) | |
| Yes | 12 (48.0) | 2 (8.0) | |
| Platinum sensitivity | 0.428 | ||
| Sensitive | 20 (66.6) | 3 (10.0) | |
| Resistance | 5 (16.7) | 2 (6.7) | |
| Chemotherapy response | 0.395 | ||
| Complete response | 20 (66.6) | 3 (10.0) | |
| Partial response | 2 (6.7) | 0 (0) | |
| Stable disease | 0 (0) | 0 (0) | |
| Progressive disease | 3 (10.0) | 2 (6.7) | |
HIF-1α expression has been dichotomized into low and high using the median immunoreactive score as the cutoff value
*Results are median with range in square brackets
BMI = body mass index, FIGO = the International Federation of Gynecology and Obstetrics