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. 2018 Jan 3;38(1):32–50. doi: 10.1523/JNEUROSCI.1348-17.2017

Figure 9.

Figure 9.

circDLGAP4/miR-143 affects the ischemic stroke outcome by regulating EndoMT associated with cerebrovascular integrity. circDLGAP4 levels were significantly decreased in the plasma of AIS patients and in the mouse stroke model. circDLGAP4, identified as ceRNA, functions as an endogenous miR-143 sponge to sequester miR-143, resulting in the inhibition of HECTD1 expression. Decreased HECTD1 expression enhanced EndoMT by decreasing TJP expression with concomitant increased expression of mesenchymal cell markers. circDLGAP4 overexpression significantly inhibited EndoMT and attenuated BBB damage in the tMCAO mouse stroke model.