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. 2019 Aug 22;14(8):e0220254. doi: 10.1371/journal.pone.0220254

Fig 5. Genetic associations with CSF PCSK9 levels, Alzheimer’s disease risk and specific biomarkers.

Fig 5

Genetic associations with A) CSF PCSK9 levels measured by ELISA in 82 cognitively normal subjects for which full genetic data was available. Intronic SNPs rs4927193 and rs499718 reached significance for PCSK9 locus (-log10(P) for a total of 168 SNPs = 3.5). Genetic associations of rs4927193 and rs499718 with B) Alzheimer’s disease in 1952 subjects from the QFP and 535 subjects from ADNI and C) with pTau and Tau from 384 CSF samples from ADNI according to gender. A1, allele 1; A2, allele 2; ADNI, Alzheimer’s disease Neuroimaging Initiative; CSF, cerebrospinal fluid; OR, odds ratio; PREVENT-AD, pre-symptomatic evaluation of experimental or novel treatments for Alzheimer’s disease; PCSK9, proprotein convertase subtilisin/kexin type 9; pTau, phosphorylated Tau; QFP, Quebec founder population; SNP, single nucleotide polymorphism.