Table 1. Comparison of patient characteristics and laboratory data at dialysis initiation.
| Variables | Overall (n = 1,520) |
Survival without CV events (n = 828) |
CV events or all-cause death (n = 692) |
P-value | Missing (%) |
|---|---|---|---|---|---|
| Age* (years old) | 70 (60, 77) | 65.5 (55, 74) | 74 (65, 80) | < 0.001 | 0.0 |
| Female sex (%) | 492 (32.4) | 306 (37.0) | 186 (26.9) | < 0.001 | 0.0 |
| Diabetes mellitus (%) | 812 (53.4) | 404 (48.8) | 408 (59.0) | < 0.001 | 0.0 |
| History of CAD (%) | 255 (16.8) | 89 (10.8) | 166 (24.0) | < 0.001 | 0.2 |
| History of stroke (%) | 243 (16.0) | 97 (11.7) | 146 (21.1) | < 0.001 | 0.0 |
| History of malignancy (%) | 162 (10.7) | 65 (7.9) | 97 (14.1) | < 0.001 | 0.0 |
| BMI (kg/m2) | 23.5 (4.4) | 24.0 (4.6) | 22.9 (4.0) | 0.008 | 0.0 |
| SBP (mmHg) | 151 (26) | 153 (25) | 149 (27) | 0.047 | 0.9 |
| DBP (mmHg) | 77 (15) | 79 (15) | 74 (15) | 0.130 | 0.9 |
| Barthel Index* | 100 (90,100) | 100 (100, 100) | 100 (65, 100) | < 0.001 | 1.7 |
| Aortic calcification (%) | 590 (38.8) | 239 (29.1) | 351 (50.9) | < 0.001 | 0.7 |
| Laboratory data | |||||
| Hemoglobin (g/dL) | 9.4 (1.5) | 9.4 (1.6) | 9.3 (1.5) | 0.377 | 0.0 |
| Albumin (g/dL) | 3.20 (0.60) | 3.26 (0.61) | 3.13 (0.57) | 0.110 | 0.9 |
| Uric Acid (mg/dL) | 8.8 (2.4) | 8.7 (2.3) | 8.9 (2.6) | 0.044 | 2.2 |
| BUN (mg/dL) | 91.8 (30.5) | 91.4 (30.2) | 92.2 (30.8) | 0.235 | 0.0 |
| Creatinine (mg/dL) | 8.97 (3.21) | 9.51 (3.42) | 8.31 (2.79) | < 0.001 | 0.0 |
| eGFR (ml/min/1.73m2) | 5.4 (2.2) | 5.1 (2.1) | 5.9 (2.3) | 0.023 | 0.0 |
| Potassium (mEq/L) | 4.6 (0.8) | 4.6 (0.8) | 4.5 (0.9) | 0.169 | 0.0 |
| Adjusted calcium (mg/dL) | 8.6 (1.1) | 8.5 (1.1) | 8.7 (1.0) | 0.022 | 0.3 |
| Phosphate (mg/dL) | 6.4 (1.9) | 6.6 (2.0) | 6.2 (1.7) | 0.096 | 1.8 |
| Intact PTH* (pg/mL) | 291 (185, 432) | 308 (202, 455) | 265 (164, 403) | 0.014 | 12.5 |
| CRP* (mg/dL) | 0.30 (0.10, 1.35) | 0.20 (0.08, 0.89) | 0.46 (0.14, 2.07) | 0.004 | 6.7 |
| Medication | |||||
| ACEIs / ARBs (%) | 917 (60.4) | 529 (64.0) | 388 (56.1) | 0.002 | 0.1 |
| beta blockers (%) | 528 (34.7) | 258 (31.2) | 270 (39.0) | 0.001 | 0.0 |
| VDRA (%) | 412 (27.1) | 247 (29.8) | 165 (23.8) | 0.009 | 0.0 |
| Phosphate binders (%) | 532 (35.0) | 344 (41.5) | 188 (27.2) | < 0.001 | 0.0 |
Data are shown as mean (standard deviation), value (%), or *median (1st quartile, 3rd quartile) as appropriate. CV, cardiovascular; CAD, coronary artery disease; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; PTH, parathyroid hormone; CRP, C-reactive protein; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; VDRA, vitamin D receptor activator