Figure 5.

Consolidation of second-order fear requires CaMKII/CaMKIV activation in the BLA but not ERK/MAPK and PKA/PKC activation. a, Experimental timeline of second-order conditioning and retraining with first-order conditioning. b, Percentage freezing to S2 across test for KN-62- and vehicle-treated rats. c, Percentage freezing to S2 across test (left), S2 across first-order acquisition (middle), and S2 across test (right) for U0126- and vehicle-treated rats. d, Percentage freezing to S2 across test (left), S2 across first-order acquisition (middle), and S2 across test (right) for H7- and vehicle-treated rats. Drug-treated rats are shown with filled squares and vehicle-treated rats are shown with open squares. Data are represented as mean ± SEM.