Figure 7.

Consolidation of second-order fear is dependent on DNA methylation and transcription but not de novo protein synthesis in the BLA. a, Experimental timeline of second-order conditioning and retraining with first-order conditioning. b, Percentage freezing to S2 across test for actinomycin-d- and vehicle-treated rats. c, Percentage freezing to S2 across test RG108-, 5-AZA-, and vehicle-treated rats. d, Percentage freezing to S2 across test (left), S2 across first-order acquisition (middle), and S2 across test (right) for cycloheximide- and vehicle-treated rats. Drug-treated rats are shown with filled squares and circle and vehicle-treated rats are shown with open squares. Data are represented as mean ± SEM.