Figure 4.

Effects of PFC D1R activation on the recall of suprathreshold fear memory and morphine reward CPP behaviors. A, Relative to VEH (n = 6) controls, intra-PFC D1R activation with SKF81297 immediately before the recall test, dose-dependently blocks the recall of suprathreshold fear memories demonstrated by significantly lower levels of associative freezing in rats receiving 10 ng (n = 8) or 100 ng (n = 8) of intra-PFC SKF81297. B, Blockade of suprathreshold fear memory recall with SKF81297 similarly blocks the potentiation of subthreshold morphine reward CPP, demonstrated by attenuated morphine environment preferences in rats receiving 10 or 100 ng intra-PFC SKF81297. **p < 0.01.