Figure 9.

Levcromakalim inhibits CSD-evoked acute and prolonged meningeal afferent activation. A, B, Examples of single-unit recording of an A-δ afferent (A) and a C afferent (B), combined with laser Doppler flowmetry, depicting the lack of acute and prolonged afferents following the elicitation of CSD with a pinprick in animals treated with levcromakalim. C, In the presence of levcromakalim, only one C afferent became acutely activated (open square outside the minimum/maximum box). D, Prolonged activation was noted only in one A-δ and three C afferents (open circle and squares outside the minimum/maximum box). PP, Pinprick.