Figure 4.

Proliferation of oligodendroglial subpopulations vulnerable to secondary degeneration in vivo. Oligodendroglia of varying maturity were identified with antibodies to NG2/olig2 (OPCs), O4 (premyelinating oligodendrocytes), and CC1 (mature oligodendrocytes). Proliferating subpopulations were distinguished by EdU⁺ labeling and were observed at varying time points after injury in (a) OPCs, (b) O4s, and (c) CC1⁺ cells. a–c, Quantification of the mean densities ± SEM of OPCs, O4, and CC1⁺ cells, respectively. Black bars represent densities of EdU⁻ cells. Gray bars represent densities of EdU⁺ cells. ^#p ≤ 0.05, differences in the number of EdU⁺ cell numbers from control. *p ≤ 0.05, differences in the total density (sum of EdU⁻ and EdU⁺ subpopulations) compared with control.