Figure 1.

Pharmacological inhibition of dAlk activity enhances STM and LTM. Mean PIs (bars) ± SEMs (error bars) are shown. The number of experimental replicates (n) are indicated within the bars. *Significant differences denoted by horizontal line pairs. Left, TAE684 administration 100 nm or 1 μm to w¹¹¹⁸ flies enhanced their learning/3 min STM performance in a high-resolution limited training protocol (1 cycle of 3 CS/US pairings). Right, TAE684 administration to w¹¹¹⁸ flies enhanced their 24 h LTM performance. LTM performance was obtained using the typical spaced training protocol of 5 cycles of 12 CS/US pairings, each cycle separated (spaced) by a 15 min rest interval.