Table 2.

SHIRPA primary screen score in CON (n = 22) and KO (n = 21) adult mice

	CON	KO	p-value
Viewing jar
Body position	3 ± 0	3 ± 0	1.0000
Spontaneous activity	1.22 ± 0.09	1.23 ± 0.09	0.9208
Respiration rate	2.09 ± 0.06	2.04 ± 0.05	0.5869
Tremor	0 ± 0	0 ± 0	1.0000
Urination	0.045 ± 0.04	0.09 ± 0.06	0.5358
Defecation	1.45 ± 0.29	1.66 ± 0.4	0.6736
Arena
Transfer arousal	4.86 ± 0.07	5 ± 0	0.0829
Locomotor activity	26.45 ± 1.27	23.04 ± 0.94	0.0387*
Palpebral closure	0 ± 0	0 ± 0	0.0990
Piloerection	0 ± 0	0 ± 0	1.0000
Startle response	0.68 ± 0.1	0.42 ± 0.11	0.0990
Gait	0 ± 0	0 ± 0	1.0000
Pelvic elevation	2 ± 0	2 ± 0	1.0000
Tail elevation	1.04 ± 0.04	1.14 ± 0.1	0.3884
Touch escape	1.59 ± 0.16	1.47 ± 0.16	0.6129
Positional passivity	0 ± 0	0 ± 0	1.0000
Trunk curl	1 ± 0	1 ± 0	1.0000
Limb grasping	1 ± 0	1 ± 0	1.0000
Whisker brush	2.14 ± 0.14	2 ± 0	0.1985
Above arena
Abnormal behavior	0.36 ± 0.10	0.42 ± 0.11	0.6736
Visual placing	3.13 ± 0.13	2.71 ± 0.14	0.0370*
Grip strength	2 ± 0.14	1.61 ± 0.11	0.0449*
Wire maneuver	1.18 ± 0.21	2 ± 0.23	0.0146*
Body tone	1.36 ± 0.1	1.09 ± 0.06	0.0379*
Pinna reflex	1.22 ± 0.09	1.04 ± 0.04	0.0934
Corneal reflex	1 ± 0	1 ± 0	1.0000
Toe pinch	2.95 ± 0.07	2.95 ± 0.04	1.0000
Supine restraint
Body length	9.81 ± 0.11	9.75 ± 0.12	0.8077
Skin color	1 ± 0	1 ± 0	1.0000
Limb tone	1.63 ± 0.1	1.4 ± 0.11	0.1316
Lacrimation	0 ± 0	0 ± 0	1.0000
Salivation	0 ± 0	0 ± 0	1.0000
Provoked biting	1 ± 0	0.95 ± 0.05	0.3006
Righting reflex	0 ± 0	0 ± 0	1.0000
Contact righting	1 ± 0	1 ± 0	1.0000
Negative geotaxis	0.09 ± 0.09	0.4 ± 0.18	0.1284
Fear	0 ± 0	0 ± 0	1.0000
Irritability	1 ± 0	1 ± 0	1.0000
Aggression	0.86 ± 0.07	0.95 ± 0.05	0.3538
Vocalization	0.81 ± 0.08	0.85 ± 0.08	0.7927
Penlight vision	0.875 ± 0.125	1 ± 0	0.2305
Body weight	39.21 ± 2.45	33.56 ± 3.35	0.4272

*Significant difference between the CON and KO groups as analyzed by unpaired t test.