Table 1.

Assumption in modelling newborn screening for CAH

Parameter definition (notation in fig. 1)	Point estimatea	Range	Reference
Incidence of CAH			13
SW and SV combined (incidence)	1 in 17,800	1 in 25,000,
		1 in 12,000
Proportion of SW among SW and SV (prop_sw)	0.65
Sensitivity of early clinical recognition			11, 12, 14
SW (sen_cl_sw)	55%	45–65%
SV (sen_cl_sv)	45%	15–75%
Screen false positive rate (false_pos)	0.5%	0.1–1.0%	13
Sensitivity of detection with screening			11
SW (sen_sw)	1.0
SV (sen_sv)	0.40	0.3–0.9
Cost of screening per one specimen (c_test), USD	4.15	2.30–6.00	8, 12
Cost of follow-up and confirmatory test per screen positive (c_follow), USD	216	130–637	12
Reduced cost of hospitalization per male SW case (c_hosp), USD	6,000		12, 17
SW mortality without screening (mr_sw)	4.2%	2.0–9.0%	7, 16, 18, 26
Reduction in SW mortality with screening (mr_reduce)	80%	74–86%

^aAlso used as a mode in a triangle distribution in probabilistic analysis. All cost values were in 2005 USD.

CAH = Congenital adrenal hyperplasia; SW = salt wasting; SV = simple virilizing.