Mailed outreach was associated with a pooled 2.6-fold relative increase in screening completion for all studies, a 1.79-fold relative increase for studies employing FIT, and a 2.18-fold relative increase for studies employing gFOBT. Weights are from random effects analysis. CRC, colorectal cancer; FIT, fecal immunochemical test; gFOBT, guaiac fecal occult blood test; RD, relative difference.