Table 3.
Luminal Aa | Luminal Bb | Non-luminal HER2- expressingc | Triple-negatived | |
---|---|---|---|---|
Incidence | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) |
Age at diagnosis (years) | ||||
20–39 | 0.62 (0.56–0.68) | 1.56 (1.35–1.80) | 1.22 (0.10–1.50) | 1.77 (1.54–2.02) |
40–49 | 0.95 (0.89–1.02) | 1.10 (1.00–1.21) | 0.87 (0.76–1.01) | 1.10 (1.00–1.20) |
50–64 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
≥65 | 1.22 (1.16–1.29) | 0.67 (0.61–0.73) | 0.61 (0.54–0.69) | 0.84 (0.77–0.92) |
Race/ethnicity | ||||
NHW | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
NHB | 0.59 (0.55–0.63) | 0.93 (0.82–1.05) | 1.31 (1.12–1.53) | 2.15 (1.95–2.36) |
API | 0.78 (0.71–0.86) | 1.24 (1.06–1.44) | 1.55 (1.27–1.90) | 0.94 (0.80–1.11) |
Hispanic | 0.76 (0.70–0.82) | 1.05 (0.92–1.19) | 1.20 (1.00–1.44) | 1.19 (1.05–1.35) |
Mortality | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) |
Age at diagnosis (years) | ||||
20–39 | 0.96 (0.74–1.25) | 0.81 (0.50–1.30) | 1.10 (0.66–1.84) | 0.99 (0.74–1.34) |
40–49 | 0.80 (0.68–0.95) | 0.65 (0.43–0.97) | 0.75 (0.49–1.17) | 1.03 (0.82–1.30) |
50–64 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
≥65 | 1.51 (1.33–1.71) | 1.69 (1.28–2.24) | 2.21 (1.62–3.01) | 1.25 (1.03–1.53) |
Race/ethnicity | ||||
NHW | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
NHB | 1.64 (1.41–1.91) | 1.54 (1.10–2.15) | 1.34 (0.95–1.91) | 1.28 (1.05–1.56) |
API | 1.00 (0.76–1.31) | 0.59 (0.28–1.25) | 0.99 (0.56–1.74) | 1.00 (0.69–1.46) |
Hispanic | 0.94 (0.75–1.17) | 1.06 (0.68–1.64) | 0.81 (0.47–1.39) | 1.14 (0.86–1.52) |
NOTE: Risk estimates and 95% confidence intervals (CI) were generated using logistic regression for incidence and Cox proportional hazards regression for breast cancer specific mortality; adjusted for age, race/ethnicity and stage at diagnosis. Bolded values represent statistical significance.
Luminal A (ER+ and/or PR+/HER2-);
Luminal B (ER+ and/or PR+/HER2+);
Non-luminal HER2-expressing (ER-/PR-/HER2+);
Triple negative (ER-/PR-/HER2-)