. Author manuscript; available in PMC: 2020 Oct 1.

Published in final edited form as: Neuromodulation. 2019 Feb 22;22(7):781–789. doi: 10.1111/ner.12925

Table 1:

Comparison of analgesic and flare producing activity of morphine and DMT-DALDA

	Antinociceptive dose ^a (Bolus delivery )	Antinociceptive Concentration ^b (Chronic infusion)	Flare producing Concentration ^c (Intradermal)
48-80	-	-	0.7 mM (0.3-1.6)
Morphine	30,000 pmol/10μL	37,500 nmol/hr	1.5 mM (0.4-6.0)
DMT-DALDA	10pmol/10μL	3 pmol/hr	2.3 mM (1.2-5.8)
Dose ratio (Morphine/ DMT-DALDA)	3000	12,500	0.6

^a:

Data from [6]. Minimum dose in rats producing maximum effect upon thermal escape. Bolus delivery; dose delivered in 10 μL

^b:

Data from this paper: Rat 14-day infusion; 0.5 μL/hr.

^c:

Data from this paper representing concentration of drug resulting in a standard flare area of 50 mm²