Table 2.
Behavioural performance
| HC | CHR-CBD | CHR-PLB | Pairwise analysis | |||
|---|---|---|---|---|---|---|
| HC-vs-CHR-PLB | HC-vs-CHR-PLB | |||||
| Mean monetary reward £GBP (SD) | 41.00 (6.63) | 37.48 (12.14) | 36.13 (11.97) | p = 0.150a | p = 0.751a | |
| Accuracy (successful hits on target) % | ||||||
| Overall | 63.5 | 60.4 | 59.3 |
Group exp(B) = 1.147 (CI 0.981–1.341), p = 0.085b Condition exp(B) = 0.639 (CI 0.546–0.747), p < 0.001b Condition ✲ group exp(B) = 0.841 (CI 0.615–1.149), p = 0.276b |
Group exp(B) = 0.985 (CI 0.837–1.159), p = 0.855b Condition exp(B) = 0.616 (CI 0.0.523–0.724), p < 0.001b Condition ✲ group exp(B) = 0.780 (CI 0.564–1.080), p = 0.134b |
|
| Neutral | 53.9 | 49.2 | 52.7 | |||
| Salience | 66.7 | 64.1 | 61.5 | |||
| Mean reaction time/ms > 100 ms (SD) | ||||||
| Overall | 243.13 (44.97) | 251.31 (52.19) | 245.70 (46.82) |
Group F(1,3275) = 0.207, p = 0.649c Condition F(1,3275) = 36.60, p < 0.0013 Condition ✲ group F(1,3275) = 2.974, p = 0.085c |
Group F(1,3151) = 16.67, p < 0.001c Condition F(1,3151) = 51.500, p < 0.001c Condition ✲ group F(1,3151) = 0.000, p = 0.992c |
|
| Neutral | 254.32 (49.36) | 262.68 (58.60) | 251.93 (52.02) | |||
| Salience | 239.69 (42.97) | 248.00 (49.72) | 243.79 (44.96) | |||
| False starts % | ||||||
| Overall | 0.9 | 1.8 | 3.2 |
Group exp(B) = 4.630, (CI 2.054–10.437), p < 0.001b Condition exp(B) = 1.446 (CI 0.642–3.260), p = 0.374b Condition ✲ group exp(B) = 2.224 (CI 0.438–11.303), p = 0.335b |
Group exp(B) = 1.678 (CI 0.970–2.902), p = 0.064b Condition exp(B) = 0.875 (CI 0.506–1.513), p = 0.632b Condition ✲ group exp(B) = 0.814 (CI 0.272–2.435), p = 0.712b |
|
| Neutral | 0.5 | 2.2 | 3.2 | |||
| Salience | 1.0 | 1.7 | 3.1 | |||
| Delayed response % | ||||||
| Overall | 33.2 | 32.8 | 35.0 |
Group exp(B) = 0.995, (CI 0.843–1.175), p = 0.953b Condition exp(B) = 0.733 (CI 0.621–0.866, p < 0.001b Condition ✲ group exp(B) = 0.816 (CI 0.585–1.139), p = 0.232b |
Group exp(B) = 1.035 (CI 0.867–1.235), p = 0.704b Condition exp(B) = 0.747 (CI 0.626–0.892), p = 0.001b Condition ✲ group exp(B) = 0.848 (CI 0.595–1.208), p = 0.362b |
|
| Neutral | 40.3 | 39.6 | 38.8 | |||
| Salience | 31.0 | 30.8 | 33.9 | |||
| Trial response % | ||||||
| Overall | 96.8 | 93.0 | 96.6 |
Group exp(B) = 0.939, (CI 0.624–1.415), p = 0.765b Condition exp(B) = 7.667 (CI 5.092–11.546), p < 0.001b Condition ✲ group exp(B) = 0.810 (CI 0.488–2.507), p = 0.810b |
Group exp(B) = 2.330 (CI 1.635–3.321), p < 0.001b Condition exp(B) = 5.754 (CI 4.037–8.202), p < 0.001b Condition ✲ group exp(B) = 0.623 (CI 0.307–1.265), p = 0.190b |
|
| Neutral | 90.8 | 84.1 | 90.7 | |||
| Salience | 98.8 | 96.0 | 98.6 | |||
HC healthy control group, CHR-CBD clinical-high risk cannabidiol group, CHR-PLB clinical-high risk placebo group
aIndependent t-test
bPairwise binary logistic regression
cAnalysis of variance
Bold values indicates that the result of the statistical test was significant