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. 2019 Aug 22;9:12251. doi: 10.1038/s41598-019-48672-6

Table 1.

Temperature effect on NET indices of the median sensory axons for both normal controls (NC) and IEM patients (IEM).

Baseline Cooling
NC (n = 10) IEM (n = 4) p* NC (n = 10) IEM (n = 4) p**
Age (year) 27.7 ± 0.7 27.3 ± 3.8 1.000 27.7 ± 0.7 27.3 ± 3.8 1.000
Temperature (°C) 36.2 ± 0.3 36 ± 0.4 0.831 25.6 ± 1.4 24.4 ± 1.2 0.887
Strengthduration curve
Rheobase (mA) 1.81 ± 0.18 1.41 ± 0.23 0.724 1.92 ± 0.14 1.62 ± 0.2 0.525
SDTC (ms) 0.554 ± 0.019 0.737 ± 0.063 0.020 0.558 ± 0.013 0.66 ± 0.043 0.056
Threshold Electrotonus (TE)
TEd(1020ms) (%) 60.1 ± 2.1 59.1 ± 2.2 0.525 51.1 ± 2.2 57.4 ± 1.6 0.179
TEd(90100ms) (%) 56.8 ± 2.2 50.6 ± 3.2 0.179 56.2 ± 2 49.5 ± 1.8 0.056
TEh(1020ms) (%) −82.3 ± 3.2 −83.8 ± 3.1 0.621 −79 ± 3.1 −82.6 ± 4 0.437
TE h(90 100ms) (%) −143.9 ± 8.2 −118.6 ± 8.8 0.104 −144.1 ± 7 −131.8 ± 3.6 0.358
TE h99ms (%) −144.8 ± 8.2 −116.8 ± 9.2 0.138 −145.7 ± 6.9 −131.4 ± 3.4 0.358
TEh,slope (101140) (%/ms) 2.32 ± 0.13 2.32 ± 0.17 1.000 2.05 ± 0.1 2.42 ± 0.11 0.104
TEh,overshoot (%) 19.9 ± 1.8 23.6 ± 3.1 0.289 21.3 ± 2.1 25.7 ± 2.4 0.289
Recovery cycle
Relative refractory period (ms) 3.97 ± 0.37 4.91 ± 0.47 0.138 5.91 ± 0.79 6.61 ± 1.17 0.933
Refractoriness (%) 49.3 ± 17.1 136.3 ± 79.4 0.138 113.5 ± 30.9 98.7 ± 66.3 0.915
Superexcitability (%) −23.7 ± 1.9 −15.5 ± 1.6 0.040 −18.7 ± 2.4 −11.8 ± 5.6 0.358
Subexcitability (%) 10 ± 0.7 10.4 ± 0.5 0.438 8.2 ± 0.7 9.1 ± 0.5 0.437
Current–threshold (I/V) curve
Hyperpolarizing IV slope 0.348 ± 0.031 0.324 ± 0.042 0.832 0.283 ± 0.033 0.251 ± 0.021 0.944
IV80%(%) −290.7 ± 10.2 −236.5 ± 14.2 0.020 −320.6 ± 8.6 −301 ± 17.1 0.437
IV100%(%) −352.2 ± 12.8 −301.5 ± 21.3 0.077 −397.2 ± 11 −382.6 ± 23.6 0.525

This table made by conducting Mann–Whitney test, and the distribution was presented by mean ± S.E.M.

*Compared to NC at normal temperature.

**Compared to NC at cooling.