Table 3.

The kinetic parameters for the wild type (WT) and IEM channel models.

	WT			IEM
	k 0 (ms−1, at 25 °C)	k 1 (mV)	Q10	k 0 (ms−1, at 25 °C)	k 1 (mV)	Q10
α	100	0.08	2.1	500	0.08	2.1
β	0.55	−0.01	2.1	4	−0.01	2.1
γ	40	0.01	2.1	40	0.01	2.1
δ	2	−0.01	2.1	2	−0.01	2.1
Coff	0.5		3.2	0.5		3.2
Con	0.1		3.2	0.1		3.2
Ooff	0.004		3.2	0.004		3.2
Oon	2.5		3.2	2.5		3.2
O1O2	0.12	0.057	2	0.12	0.057	2.6
O2O1	0.001	−0.095	2	0.001	−0.095	2.6
O2I2	0.5	0.04	2	0.3	0.04	3.3
I2O2	0.06	−0.03	2	0.07	−0.03	3.3
I1I2	0.002	0.01	2.6	0.001	0.01	2.6
I2I1	0.2	−0.038	2.6	0.12	−0.038	2.6

All transition rates are expressed as k₀·e^k1*E·Q10 ^(T–T0)/10, where k₀ is the transition rate at 0 mV, k₁ is the voltage dependence constant in mV⁻¹, E is membrane potential in mV, Q₁₀ is the temperature coefficient, and T is temperature in °C (with T₀ at 25 °C). The basic kinetic parameters at room temperature are the same as those reported previously²¹, with slight changes in k₁ of δ and k₀ of I₂O₂ and O₂I₂ of the WT and IEM channels for better simulation of all of the findings in different temperatures. The main differences between the kinetics of WT and IEM channels are in k₀ of α, β, O₂I₂, I₂O₂, I₁I₂ and I₂I₁ and the temperature dependence of transition between states O₂ and I₂ (bold letters).