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. 2019 Aug 22;9:12270. doi: 10.1038/s41598-019-48800-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Opposite effects of acute exposure (7 days) to HFD on object location memory (OLM) in juvenile and adult male rats (A) Schematic representation of the experimental procedure. (B) A significant interaction between diet and age of exposure was observed in the long-term OLM [F(1, 20) = 23.7, P < 0.001]. Whereas acute exposure to HFD impaired long-term OLM in juvenile rats (***P = 0.001), HFD enhanced OLM in adults (⁺P = 0.075). (C) No significant effects were observed between the groups in the short-term OLM [F(1, 32) = 1.4].