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. 2019 Aug 22;9:12270. doi: 10.1038/s41598-019-48800-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Opposite effects of acute exposure (7 days) to HFD on hippocampal plasticity in juvenile and adult male rats. (A) Schematic representation of the experimental procedure. (B) Time course plots of normalized field post-synaptic potentials (fPSPs) recorded in vivo before and after theta burst stimulation (TBS) of the Schaffer collateral-CA1 pathway. (C) Bar histogram representing percentage of long-term potentiation (LTP) during the 40 min after TBS in the same groups as described in (B). A significant interaction between diet and age of exposure was observed [F(1, 19) = 24.8, P < 0.001] with exposure to HFD impairing LTP in juvenile animals (***P = 0.002) whereas in adults, HFD exposure enhanced LTP (*P = 0.04).