Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 22;9:12270. doi: 10.1038/s41598-019-48800-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effects of glucocorticoid receptors blockade on juvenile HFD-induced impairments of object location memory and hippocampal plasticity. (A) Schematic representation of the experimental procedure. (B) HFD impaired long-term OLM in vehicle (Veh)-treated juveniles, and GR blockade with RU486 (RU) rescued OLM in the HFD group without affecting OLM in CD groups [Interaction Drug × Diet: F(1, 32) = 9.15 ***P = 0.005]. (C) Time course plots of normalized field post-synaptic potentials (fPSPs) recorded in vivo before and after theta burst stimulation (TBS) of the Schaffer collateral-CA1 pathway. (D) Bar histogram representing percentage of long-term potentiation (LTP) during the 40 min after TBS in the same groups as described in (B). HFD impaired LTP in Veh-treated juveniles, whereas prior with RU treatment in HFD fed animals restored LTP [t(14) = 3.6, ***P = 0.005]. Similarly, RU also impaired the induction of LTP in CD animals [t(2) = 5.0, P = 0.001].