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. 2019 Aug 22;10:3778. doi: 10.1038/s41467-019-11378-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Resveratrol treatment reduced the interaction between ESR1 and FOXO3 but maintained the FOXO3 gene activity. a The resveratrol treatment affected the interaction between the Eleanor topologically associating domain and other A compartments. Top: Contact matrices from Hi-C, binned at 250-kb resolution. The normalized interaction frequencies of long-term estrogen deprivation (LTED) and LTED-RES cells are shown above and below the diagonal line, respectively. Middle: A/B compartments and fold changes in the contact frequencies. Positions of gained (red) and reduced (blue) contacts with the ESR1 promoter are shown. Bottom: Positions of all genes and 3C-qPCR (chromosome conformation capture–quantitative polymerase chain reaction) primers, as in Fig. 2a. b 3C-qPCR shows the relative interaction frequencies of the b site decreased by resveratrol treatment. c Relative expression levels of genes at 6q21 in LTED and LTED-RES cells. The LTED expression level was set to 1. Data presented in b, c are representative of three independent experiments (mean ± s.e.m.). P values were calculated using unpaired, two-tailed, Student’s t test (***P < 0.001, n.d. = not detected in at least one experiment)