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. 2019 Aug 22;9:12246. doi: 10.1038/s41598-019-48671-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bland-Altman plots between DTI-derived NODDI and original NODDI parameters in vivo. (A,C) show Bland-Altman plots between DTI-derived NODDI parameters in the three -shell dataset (b_All) and the original NODDI parameters in the three-shell dataset (b_All). (B,D) Show Bland-Altman plots between DTI-derived NODDI parameters in the high b-value one-shell dataset (b₃₀₀₀) and the original NODDI parameters in the three-shell dataset (b_All). Plots are coloured by their density. Blue lines show the mean ± 1.96 * SD and the red line shows the mean value. Abbreviations; NDIORIG: neurite density index estimated using the original NODDI model, ODI_ORIG: orientation dispersion index estimated using the original NODDI model, NDIDTI: neurite density index estimated using DTI-derived NODDI, ODI_DTI: orientation dispersion index estimated using DTI-derived NODDI.