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. 2019 Aug 22;9:12276. doi: 10.1038/s41598-019-48653-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Changes in concentrations of serum T₃ (ng/ml), T₄ (ng/ml X10), TSH (µIU/ml) and hepatic 5′D1 (ng/ml T₃ generated/hour/mg protein), following the administration APC (2.0 mg/kg/d) alone or T₄ + APC or T₄ + PTU. Each bar represents the mean ± SEM (n = 7). ^aP < 0.001 and ^bP < 0.01 as compared to the respective control value; whereas ^xP < 0.001 and ^yP < 0.01, as compared to the respective value of L-T₄ treated group. (b) Changes in hepatic G-6-Pase (μM of Pi liberated/h/mg protein) and Na⁺-K⁺-ATPase activity (μM of Pi liberated/h/mg of protein) following the administration APC (2.0 mg/kg/d) alone or T₄ + APC or T₄ + PTU in rats. Each vertical bar represents the mean ± SEM. (n = 7). ^aP < 0.001 as compared to the respective control value, whereas ^xP < 0.001 as compared to the value of L-T₄ treated animals.