Table 2.

Contractile responses of bladder strips.

	Control	Dapagliflozin	HFD/STZ	HFD/STZ/dapa
KCl peak, mN/mm	294 ± 98	337 ± 116	316 ± 79	365 ± 105
Carbachol peak pEC50	6.00 ± 0.20	6.04 ± 0.24	6.20 ± 0.47	5.99 ± 0.32
Carbachol peak Emax, mN/mm	548 ± 198	693 ± 258	588 ± 166	763 ± 218
Carbachol plateau, mN/mm	159 ± 47	188 ± 53	170 ± 38	189 ± 55

Data are means ± SD of 10 rats, except for HFD/STZ group (n = 9) with 2-4 strips being measured per rat. A graphical depiction of the data is shown in Figure 4 .