Table 3.
Uni and multivariate analysis for chloride parameters and mortality
| Survivors N = 258 |
Non survivors N = 155 |
HR 95% CI, p | Adjusted HRa, # 95% CI, p | |
|---|---|---|---|---|
| Hyper chloremia, n (%) | ||||
| No | 96 (37.2%) | 60 (38.7%) | 1 (ref) | |
| Yes | 162 (62.8%) | 95 (61.3%) | 0.87 [0.61;1.27], 0.509 | 0.88 [0.96; 1.00], 0.061 |
| [Chloride], mmol/l | – | – | 0.98 [0.96; 1.00], 0.193 | 0.99 [0.97; 1.01], 0.175 |
| [Chloride] max, mmol/L | 112 [107–118] | 111 [106.5–117] | 0.99 [0.97;1.01], 0.363 | 0.98 [0.96; 0;99], 0.043 |
| Delta [Chloride] > 5 mmol/L, n | ||||
| No | 103 (44.8%) | 67 (48.2%) | 1 (ref) | 1 (ref) |
| Yes | 127 (55.2%) | 72 (51.8%) | 0.88 [0.61; 1.26], 0.492 | 0.72 [0.49; 1.04], 0.081 |
| [Na–Cl] difference, mmol/L | – | – | 1.00 [0.93; 1.08], 0.942 | 1.00 [0.93; 1.09], 0.924 |
| [Na–Cl] minimal difference, mmol/L | 30 [28–32] | 30 [27–34] | 1.02 [0.98; 1.07], 0.285 | 1.03 [0.98; 1.08], 0.286 |
aAdjusted for hyperoxia group, age, MacCabe, SAPS, SOFA, Hyperlactatemia, Serum creatinine and ARDS at H0 and for the following time-dependent variable: Serum creatinine, vasopressor dose, Serum lactate and volume of fluid resuscitation
#Adjusted models were developed in the 352 patients without missing data