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. 2019 Jul 23;14:252–260. doi: 10.1016/j.omtm.2019.07.004

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© 2019 Paul-Ehrlich-Institut

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Model for the Surface Proteins Involved in Entry of GluA4-AAV

(A) Cell entry of AAV2. Cooperative binding of AAV particles to the primary attachment receptor HSPG and possibly also integrin α5β1 mediates contact to AAVR, which then leads to internalization and trafficking through the cytoplasm. (B) GluA4-AAV does not bind to HSPG because of the introduced capsid mutations (R585A and R588A; depicted as red crosses). Primary cell binding is mediated by the GluA4-receptor via the displayed DARPin. Afterward, cooperative binding to AAVR takes place leading to internalization and trafficking through the cytoplasm.