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. 2019 Aug 15;21(10):945–962. doi: 10.1016/j.neo.2019.07.002

Figure 7.

Figure 7

Tumor regression by SMAR1 via increased antigen presentation by tumor cells. (a, b and c) Ova- Ip (SIINFEKL) immunized C57BL/6 mice were injected with MO4 cells for tumor generation followed by transduction with control, adeno-SMAR1 and lenti-SMAR1 and tumor progression was studied. In-vivo imaging was done to visualize the tumor growth. (d) FACS for Ova- Ip (SIINFEKL) antigen presented by MHC I on MO4 tumor cells transduced with control and Adeno-SMAR1 virus. (e) FACS for CD8+ T-cells infiltration inside the control and Ad-SMAR1 transduced MO4 tumors. (f-i) ELISA was performed to check the serum levels of IL-2, IFNγ, IL-6 and IL-4 in lenti-SMAR1 transduced MO4 tumor containing mice compared to control at day 10 and 21 of tumor progression.