Table 1.
The effect of piperine on liver histopathologic injuries induced by AKI.
| Histopathologic damages | Experimental groups |
|||
|---|---|---|---|---|
| Sham | I/R | I/R + P10 | I/R + P20 | |
| Leukocytes infiltration | 0 | 3.4 | 0.7 | 0.4 |
| Cellular fibrosis | 0 | 4.6 | 1.6 | 0.7 |
| Sinusoidal dilatation | 1 | 5 | 1.8 | 1.2 |
| Vascular congestion | 0.9 | 5 | 2.1 | 1.1 |
| Total histopathologic score | 1.9 | 18*** | 6.2* †† | 3.4††† |
Histopathological scores in rats underwent sham surgery and received vehicle (Sham), ischemia/reperfusion and received vehicle (I/R), or piperine at 10 or 20 mg/kg (I/R + P10 and I/R + P20 groups).
*P < 0.05, ***P < 0.001, in comparison with sham group.
††P < 0.01, †††P < 0.001, in comparison with I/R group.