Table 1. Characteristics of the enrolled studies on miR-618 rs2682818 polymorphism and cancer.
First author | Year | Ethnicity | Genotyping method | Source of control | Cancer type | Cases | Controls | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total | A allele (%) | CC | AC | AA | Total | A allele (%) | CC | AC | AA | HWE | ||||||
Li et al. [25] | 2011 | Asian | TaqMan | PB | Hepatocellular carcinoma | 339 | 26.0 | 186 | 130 | 23 | 352 | 23.7 | 203 | 131 | 18 | 0.594 |
Li et al. [25] | 2011 | Asian | TaqMan | PB | Hepatocellular carcinoma | 107 | 26.2 | 55 | 48 | 4 | 105 | 27.1 | 57 | 39 | 9 | 0.533 |
Li et al. [25] | 2011 | Asian | TaqMan | PB | Nasopharyngeal carcinoma | 799 | 26.2 | 444 | 292 | 63 | 1021 | 26.4 | 551 | 401 | 69 | 0.731 |
Wang et al. [28] | 2012 | Asian | TaqMan | PB | Bladder cancer | 336 | 29.5 | C = 474 | A = 198 | 454 | 30.1 | C = 635 | A = 273 | 0.256 | ||
Zhang et al. [26] | 2012 | Asian | PCR-RFLP | PB | Breast cancer | 244 | 25.6 | 132 | 99 | 13 | 232 | 24.4 | 130 | 91 | 11 | 0.325 |
Zhang et al. [27] | 2012 | Asian | PCR-RFLP | PB | Colorectal cancer | 444 | 25.3 | 249 | 165 | 30 | 455 | 24.3 | 262 | 165 | 28 | 0.767 |
Fu et al. [16] | 2014 | Caucasian | MassARRAY | PB | Lymphoma | 349 | 14.9 | 256 | 82 | 11 | 511 | 13.4 | 383 | 119 | 9 | 0.945 |
Navarro et al. [24] | 2016 | Caucasian | PCR | PB | Chronic lymphocytic leukemia | 163 | 8.6 | 138 | 22 | 3 | 236 | 14.6 | 172 | 59 | 5 | 0.982 |
Morales et al. [13] | 2016 | Caucasian | TaqMan | PB | Breast cancer | 440 | 9.5 | 359 | 78 | 3 | 807 | 7.1 | 699 | 102 | 6 | 0.290 |
Chen et al. [23] | 2018 | Asian | TaqMan | PB | Colorectal cancer | 878 | 25.8 | 475 | 353 | 50 | 884 | 30.1 | 436 | 363 | 85 | 0.457 |
H-B: hospital based; P-B: population based; HWE: Hardy–Weinberg equilibrium, P>0.05 means conformed to HWE.